Références scientifiques

La créatine est l’un des compléments les plus étudiés au monde.

1. Créatine et fonction cognitive

2025

  • A. Smith-Ryan et al. (2025) — Creatine in women’s health: bridging the gap from menstruation through pregnancy to menopause.
  • Monika Gajda-Bathelt et al. (2025) — Creatine supplementation: bioavailability and effects on physical and cognitive performance.
  • D. Zanini et al. (2025) — Dietary Creatine and the Risk of Mental Health Conditions in the General Population.
  • Martyna Kaplińska et al. (2025) — Impact of Creatine Supplementation on Cognitive Function in Elderly: A Systematic Review.
  • Felipe Ribeiro et al. (2025) — Creatine supplementation and muscle-brain axis: a new possible mechanism?
  • John E. Giraldo et al. (2025) — Neuroprotective effects of creatine supplementation in mild TBI among contact sport athletes.

2024

  • Elena Sztemberg et al. (2024) — The effects and benefits of creatine supplementation on brain health.

2023

  • J. F. Sandkühler et al. (2023) — Effects of creatine supplementation on cognitive performance: randomized controlled study.

2022

  • K. Prokopidis et al. (2022) — Effects of creatine supplementation on memory in healthy individuals: meta-analysis.

2021

  • H. Roschel et al. (2021) — Creatine Supplementation and Brain Health.

Études de référence antérieures

  • K. Avgerinos et al. (2018) — Creatine and cognitive function in healthy individuals: systematic review.
  • E. P. Marques et al. (2019) — Creatine as a neuroprotector: an actor that can play many parts.
  • M. Beal (2011) — Neuroprotective effects of creatine.

2. Performance musculaire, force et puissance

2025

  • Weronika Kotnis et al. (2025) — Creatine Supplementation: Effects on athletic performance, cognitive processing, and long-term health.
  • Adam Sobiński et al. (2025) — Impact of creatine supplementation on physical performance, cognitive functions, and safety: systematic review.
  • Alex Anghinoni Jangada et al. (2025) — Impacto da suplementação com creatina no desempenho físico e na recuperação muscular.
  • Martyna Pacanowska et al. (2025) — How does creatine supplementation affect physical performance and muscle recovery? Literature review.

Autres études majeures

  • J. Mielgo-Ayuso et al. (2019) — Creatine supplementation and athletic performance in soccer players: systematic review and meta-analysis.
  • R. Kreider et al. (2003) — Effects of creatine supplementation on performance and training adaptations.
  • Scott C. Forbes et al. (2021) — Meta-analysis on creatine ingestion strategies and effects on lean mass and strength.
  • P. Chilibeck et al. (2017) — Creatine during resistance training: effects on muscle mass and strength.
  • Scott C. Forbes et al. (2023) — Creatine supplementation and endurance performance.
  • R. Kreider et al. (2017) — ISSN Position Stand: Safety and efficacy of creatine supplementation.

3. Composition corporelle et développement musculaire

2025

  • Daren G. Candow et al. (2025) — Creatine monohydrate supplementation for older adults and clinical populations.

2024

  • Fereshteh Pashayee-Khamene et al. (2024) — Creatine supplementation protocols with or without training interventions: GRADE systematic review on body composition.

Autres études clés

  • Shih-Hao Wu et al. (2022) — Creatine supplementation for muscle growth: scoping review of RCTs (2012–2021).
  • K. Vandenberghe et al. (1997) — Long-term creatine intake beneficial to muscle performance during resistance training.
  • Lisa A. Riesberg et al. (2016) — Beyond muscles: the untapped potential of creatine.

4. Récupération et dommages musculaires

Études récentes

  • Jiaming Yue et al. (2021) — Creatine supplementation effect on recovery following exercise-induced muscle damage: systematic review and meta-analysis.
  • Dean M. Cordingley et al. (2022) — Anti-inflammatory and anti-catabolic effects of creatine supplementation: brief review.

Certaines études rapportent des améliorations de la récupération de la force musculaire après des exercices dommageables, avec des chiffres proches ou supérieurs à 20% :

  • Une étude randomisée a montré que le groupe supplémenté en créatine avait une récupération isométrique 21% plus élevée que le groupe placebo après des exercices excentriques, ce qui correspond à une récupération de la force musculaire significativement plus rapide.
  • D’autres études et méta-analyses confirment une accélération de la récupération (force, amplitude de mouvement, réduction des marqueurs de dommages musculaires), mais la magnitude exacte varie selon les protocoles et les indicateurs mesurés.

Les études :

M. Cookeet al. (2009) - Creatine supplementation enhances muscle force recovery after eccentrically-induced muscle damage in healthy individuals

Shota Yamaguchiet al. (2024) - The Effect of Prior Creatine Intake for 28 Days on Accelerated Recovery from Exercise-Induced Muscle Damage: A Double-Blind, Randomized, Placebo-Controlled Trial

Jiaming Yueet al. (2021) - Creatine supplementation effect on recovery following exercise-induced muscle damage: A systematic review and meta-analysis of randomized controlled trials.

5. Créatine, vieillissement, sarcopénie, santé osseuse

2019

  • D. Candow et al. (2019) — Effectiveness of creatine supplementation on aging muscle and bone, with focus on falls prevention.

2016

  • B. Gualano et al. (2016) — Creatine supplementation in the aging population: effects on skeletal muscle, bone, and brain.

6. Sécurité, mythes et clarifications scientifiques

2021

  • J. Antonio et al. (2021) — Common questions and misconceptions about creatine supplementation: what does the scientific evidence really show?
  • B. Wax et al. (2021) — Creatine for exercise, sports performance and recovery.

2022

  • M. Balestrino et al. (2019) — Efficacy and safety of creatine in pathological or paraphysiological conditions.
  • R. Kreider et al. (2021) — Creatine in Health and Disease.

7. Métabolisme et mécanismes cellulaires

2025

  • Yuhui Su (2025) — Three-Dimensional Network of Creatine Metabolism: intracellular shuttle to systemic metabolic function.
  • Axel Zevallos-Aquije et al. (2025) — Physical effects of α-methyl guanidine acetic-acid consumption (creatine analog).

2023

  • D. Candow et al. (2023) — Creatine beyond muscle metabolism.

8. Synthèses générales, revues transversales et articles de vulgarisation scientifique

2024

  • Jose Antonio et al. (2024) — The Top 5 Can’t-Miss Sport Supplements.

2022

  • Scott C. Forbes et al. (2022) — Effects of creatine supplementation on brain function and health.